Profhilo Vs Polynucleotides, which is best for you.

If you’ve been researching ways to improve your skin quality, chances are you’ve come across both Profhilo and polynucleotides.

They’re two of the most talked-about treatments in aesthetics right now, and for good reason. Both are designed to improve skin health rather than change your facial structure, but they work in very different ways.

So how do you know which is right for you?

What is Profhilo?

Profhilo is a hyaluronic acid-based injectable designed to deeply hydrate the skin and stimulate collagen and elastin production.

Rather than adding volume like filler, it spreads beneath the skin to improve overall texture, hydration and radiance.

Best for:

• Dull, dehydrated skin

• Early signs of ageing

• Loss of glow

• Mild skin laxity

  
  

It’s often described as giving that “lit-from-within” look.

What are Polynucleotides?

Polynucleotides are regenerative treatments derived from DNA fragments that work by repairing and stimulating your skin at a cellular level.

They improve skin quality by encouraging tissue regeneration, improving elasticity, and supporting long-term skin health.

Best for:

• Crepey or thinning skin

• Under-eye concerns

• Acne scarring

• More advanced signs of ageing

Key Differences:

Profhilo

• Hydrates and boosts glow

• Quick results

• Minimal downtime

• Ideal for prevention and early ageing

Polynucleotides

• Repairs and regenerates skin

• Works gradually over time

• Targets more complex concerns

• Stronger focus on skin quality and structure

Which One Do I Recommend in Clinic?

This really depends on your skin, and this is where a personalised consultation is key.

In general:

• If your main concern is dullness or dehydration, I tend to recommend Profhilo

• If you’re noticing crepey skin, thinning, or under-eye changes, polynucleotides are often the better option

Quite often, we actually use both in a longer-term treatment plan.

Final Thoughts

There isn’t a “better” treatment, just the right one for you.

Both are excellent options if your goal is natural, healthy skin rather than obvious change. The key is choosing the right approach based on your skin quality, age, and long-term goals.

If you’re unsure, this is exactly what consultations are for, we can assess your skin properly and build a plan that feels right for you.